Histamine H2 receptor antagonists, such as cimetidine and ranitidine, became available in the late s and presently number among the most commonly used drugs. Cimetidine has been hypothesized to exert a cancer preventive effect on the prostate due to its ability to inhibit the binding of dihydrotestosterone to androgen receptors. Other hormonal effects of this drug include increases in serum prolactin levels and inhibition of 2-hydroxylation of estradiol.
Cimetidinesold under the brand name Tagamet among others, is a histamine H 2 receptor antagonist that inhibits stomach acid production. The development of longer-acting H 2 receptor antagonists with fewer drug interactions and adverse effects, such as ranitidine and famotidinedecreased the use of cimetidine, and though it is still used, cimetidine is no longer among the more widely used of the H 2 receptor antagonists. Cimetidine was discovered in and came into commercial use in
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Cimetidine is used to reduce the pain of ulcer and heartburn or to assist in the healing of ulcers and damage caused by gastroesophageal reflux disease GERD. Cimetidine is also used to prevent ulcers in certain circumstances and to treat certain conditions that are associated with oversecretion of acid by the stomach i. The medication works by reducing the amount of acid secreted by the stomach. Your doctor may have suggested this medication for conditions other than those listed in these drug information articles.
Do not start, stop, or change the dose of any drug your child takes without checking with the doctor. All drugs may cause side effects. However, many people have no side effects or only have minor side effects.
Purpose - The study was conducted to examine whether use of cimetidine is associated with the risk of cancer, with special attention to cancers of the breast and prostate because cimetidine increases estradiol levels and interferes with androgen binding. Methods - Individuals who received a prescription of cimetidine were identified from two computerized pharmacy databases of medications dispensed at Northern California Kaiser Permanente between and Users of ranitidine, a histamine-2 receptor antagonist that does not appear to influence estrogen levels or androgen binding, and non-users of either cimetidine or ranitidine, were also identified from these databases.
Medically reviewed by Drugs. Last updated on May 5, This is not a list of all drugs or health problems that interact with this medicine cimetidine tablets.
Male mammal glandular tissue, under particular conditions, can proliferate and increase in volume. Gynecomastia feels to touch like a rubbery mass extending concentrically under the areola and can affect one mammary gland only or both. This more or less pronounced volume-increase of the mammary glandular tissue can be associated with discomfort or pain. Sometimes adipose tissue accumulation at breast level can be mistaken for real gynecomastia.
Drug information provided by: IBM Micromedex. Histamine H2-receptor antagonists, also known as H2-blockers, are used to treat duodenal ulcers and prevent their return. They are also used to treat gastric ulcers and for some conditions, such as Zollinger-Ellison disease, in which the stomach produces too much acid.